THE ARCB GENE OF ESCHERICHIA-COLI ENCODES A SENSOR-REGULATOR PROTEIN FOR ANAEROBIC REPRESSION OF THE ARC MODULON

被引：165

作者：

IUCHI, S

FUJIWARA, T

LIN, ECC

机构：

[1] HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOLEC GENET,200 LONGWOOD AVE,BOSTON,MA 02115

[2] HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115

来源：

MOLECULAR MICROBIOLOGY | 1990年 / 4卷 / 05期

关键词：

D O I：

10.1111/j.1365-2958.1990.tb00642.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The arcA (dye) and arcB genes of Escherichia coli are responsible for anaerobic repression of target operons and regulons of aerobic function (the arc modulon). The amino acid sequence of ArcA (Dye) indicated that it is the regulator protein of a two‐component control system. Here we show that ArcB is a membrane sensor protein on the basis of its deduced amino acid sequence (778 residues), hydropathicity profile, and cellular distribution. On the carboxyl end of the ArcB sequence there is an additional domain showing homology with conserved regions of regulator proteins. Deletion into this domain destroyed ArcB function. ArcB conserved a histidine residue for autophosphorylation of the sensor proteins, and aspartic residues important for the regulator proteins. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：715 / 727

页数：13

共 59 条

[1] ALBIN R, 1986, J BIOL CHEM, V261, P4698
[2] NUCLEOTIDE-SEQUENCE OF THE PHOM REGION OF ESCHERICHIA-COLI - 4 OPEN READING FRAMES MAY CONSTITUTE AN OPERON
AMEMURA, M
MAKINO, K
SHINAGAWA, H
NAKATA, A
[J]. JOURNAL OF BACTERIOLOGY, 1986, 168 (01) : 294 - 302
[3] NUCLEOTIDE-SEQUENCE OF THE FNR-REGULATED FUMARASE GENE (FUMB) OF ESCHERICHIA-COLI K-12
BELL, PJ
ANDREWS, SC
SIVAK, MN
GUEST, JR
[J]. JOURNAL OF BACTERIOLOGY, 1989, 171 (06) : 3494 - 3503
[4] POSITIVE SELECTION FOR LOSS OF TETRACYCLINE RESISTANCE
BOCHNER, BR
HUANG, HC
SCHIEVEN, GL
AMES, BN
[J]. JOURNAL OF BACTERIOLOGY, 1980, 143 (02) : 926 - 933
[5] BOURRET RB, 1989, J BIOL CHEM, V264, P7085
[6] NITROGEN-FIXATION SPECIFIC REGULATORY GENES OF KLEBSIELLA-PNEUMONIAE AND RHIZOBIUM-MELILOTI SHARE HOMOLOGY WITH THE GENERAL NITROGEN REGULATORY GENE NTRC OF K-PNEUMONIAE
BUIKEMA, WJ
SZETO, WW
LEMLEY, PV
ORMEJOHNSON, WH
AUSUBEL, FM
[J]. NUCLEIC ACIDS RESEARCH, 1985, 13 (12) : 4539 - 4555
[7] IDENTIFICATION OF THE DYE GENE-PRODUCT, MUTATIONAL LOSS OF WHICH ALTERS ENVELOPE PROTEIN-COMPOSITION AND ALSO AFFECTS SEX FACTOR-F EXPRESSION IN ESCHERICHIA-COLI K-12
BUXTON, RS
DRURY, LS
[J]. MOLECULAR & GENERAL GENETICS, 1984, 194 (1-2): : 241 - 247
[8] PRIMARY CHARACTERIZATION OF THE PROTEIN PRODUCTS OF THE ESCHERICHIA-COLI OMPR LOCUS - STRUCTURE AND REGULATION OF SYNTHESIS OF THE OMPR AND ENVZ PROTEINS
COMEAU, DE
IKENAKA, K
TSUNG, K
INOUYE, M
[J]. JOURNAL OF BACTERIOLOGY, 1985, 164 (02) : 578 - 584
[9] CASCADE REGULATION OF NIF GENE-EXPRESSION IN RHIZOBIUM-MELILOTI
DAVID, M
DAVERAN, ML
BATUT, J
DEDIEU, A
DOMERGUE, O
GHAI, J
HERTIG, C
BOISTARD, P
KAHN, D
[J]. CELL, 1988, 54 (05) : 671 - 683
[10] DRURY LS, 1985, J BIOL CHEM, V260, P4236

← 1 2 3 4 5 6 →