GRANULE CELLS IN THE VENTRAL, BUT NOT DORSAL, DENTATE GYRUS ARE ESSENTIAL FOR KAINIC ACID-INDUCED WET DOG SHAKES

被引：18

作者：

GRIMES, LM

EARNHARDT, TS

MITCHELL, CL

TILSON, HA

HONG, JS

机构：

[1] NIEHS,MOLEC & INTEGRAT NEUROSCI LAB,POB 12233,RES TRIANGLE PK,NC 27709

[2] UNIV N CAROLINA,CURRICULUM TOXICOL,CHAPEL HILL,NC 27514

[3] UNIV N CAROLINA,BIOL SCI RES CTR,CHAPEL HILL,NC 27514

来源：

BRAIN RESEARCH | 1990年 / 514卷 / 01期

关键词：

Colchicine; Dentate granule cell; Dorsal hippocampus; Kainate; Ventral hippocampus; Wet dog shakes;

D O I：

10.1016/0006-8993(90)90453-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intrahippocampal injections of colchicine selectively destroy dentate granule cells. Wet dog shaking elicited by systemic administration of kainic acid is eliminated by bilateral destruction of ventral dentate granule cells but unaffected by bilateral destruction of dorsal dentate granule cells. This implies that ventral dentate granule cells are essential for the generationn of kainic acid-induced wet dog shakes. © 1990.

引用

页码：167 / 170

页数：4

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BARNES MI, UNPUB BRAIN RES

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