MORPHINE IN POSTMORTEM BLOOD - ITS IMPORTANCE FOR THE DIAGNOSIS OF DEATHS ASSOCIATED WITH OPIATE ADDICTION

被引：33

作者：

STAUB, C

JEANMONOD, R

FRYC, O

机构：

[1] Institute of Forensic Medicine, University of Geneva, Geneva 4

来源：

INTERNATIONAL JOURNAL OF LEGAL MEDICINE | 1990年 / 104卷 / 01期

关键词：

MORPHINE; BLOOD; DEATH; HPLC; OVERDOSE;

D O I：

10.1007/BF01816482

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

This article describes an analytical method for the determination of morphine, the active metabolite of heroin, in post-mortem blood by HPLC with electrochemical detection. An extraction technique allowing the determination of free and total morphine (free morphine + morphine glucuronide) was used. Blood morphine levels in postmortem cases are reported and the ratio of free to total morphine was measured in 52 cases obtained at autopsy. The importance of this ratio is discussed in relation to the circumstances of the death.

引用

页码：39 / 42

页数：4

共 12 条

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Baselt R.C., 1989, DISPOSITION TOXIC DR

[2]

CHESHER GB, 1989, ALCOHOL DRUGS DRIVIN, V5, P111

[3]

JANE I, 1975, J CHROMATOGR, V109, P37

[4] DEATH CAUSED BY DRUG-ADDICTION - A REVIEW OF THE EXPERIENCES IN HAMBURG AND THE SITUATION IN THE FEDERAL-REPUBLIC-OF-GERMANY IN COMPARISON WITH THE LITERATURE [J].