GRANULOSA-CELLS AS A SOURCE AND TARGET ORGAN FOR TUMOR NECROSIS FACTOR-ALPHA

被引:145
作者
ZOLTI, M
MEIROM, R
SHEMESH, M
WOLLACH, D
MASHIACH, S
SHORE, L
RAFAEL, ZB
机构
[1] KIMRON VET INST, DEPT HORMONE RES, POB 12, IL-50200 BET DAGAN, ISRAEL
[2] KIMRON VET INST, DEPT IMMUNOL, BET DAGAN, ISRAEL
[3] WEIZMANN INST SCI, DEPT VIROL, IL-76100 REHOVOT, ISRAEL
来源
FEBS LETTERS | 1990年 / 261卷 / 02期
关键词
(Human; Bovine); Follicle-stimulating hormone; Granulosa cell; Ovarian follicle; Tumor necrosis factor;
D O I
10.1016/0014-5793(90)80565-Z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Tumor necrosis factor (TNF-α), a 17 kDa cytokine, is a product of activated macrophages which was recently shown to be produced by rat and bovine granulosa cells. In the present work, human granulosa cells derived from preovulatory follicles were used. It was demonstrated that human granulosa cells produce TNF-α (5-10 units/300 000 cells per 15 h). This production was increased by addition of follicle-stimulating hormone or by a combination of human chorionic gonadotrophin and CSF to the culture media. TNF was also found in bovine follicular fluid and the concentration was higher in the periovulatory than mid-cycle follicles. TNF-α was found to increase prostaglandin F-2α production by human granulosa cells (P < 0.001). We conclude that granulosa cells are both a source and target organ for TNF-α. © 1990.
引用
收藏
页码:253 / 255
页数:3
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