SOME DISTURBANCES OF ACROSOMAL DEVELOPMENT AND FUNCTION IN HUMAN SPERMATOZOA

被引：58

作者：

SCHILL, WB

机构：

[1] Department of Dermatology and Andrology, Justus Liebig University, W-6300 Giessen

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 07期

关键词：

ACROSOMAL DEVELOPMENT; ACROSOMAL DEFECTS; ACROSOMAL FUNCTION; ACROSIN; ACROSOME REACTION;

D O I：

10.1093/oxfordjournals.humrep.a137471

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Disturbances of acrosomal development and function significantly impair the fertilizing capacity of spermatozoa. Therefore, evaluation of acrosomal morphology and function is of particular importance in the diagnostic testing of male infertility. Acrosomal disturbances include either specific defects showing a complete absence of certain acrosomal structures or various acrosomal malformations in combination with nuclear or flagellar defects which indicate acquired testicular disorders. As examples of specific acrosomal defects, the syndrome of round-headed spermatozoa (globozoospermia), the crater defect syndrome and the syndrome of decapitated spermatozoa are discussed. In addition to disturbances of acrosomal morphology, the assessment of acrosomal proteinase activity and the acrosome reaction as a method of evaluating impaired acrosomal functions is discussed. Clinical examples demonstrate the importance of these sperm function tests in the fertility testing of infertile men.

引用

页码：969 / 978

页数：10

共 60 条

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