THE CHARCOT-BOUCHARD ANEURYSM CONTROVERSY - IMPACT OF A NEW HISTOLOGIC TECHNIQUE

被引:53
作者
CHALLA, VR
MOODY, DM
BELL, MA
机构
[1] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,CTR CEREBROVASC RES STROKE,WINSTON SALEM,NC 27103
[2] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT RADIOL,WINSTON SALEM,NC 27103
[3] WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT NEUROBIOL & ANAT,WINSTON SALEM,NC 27103
关键词
APOPLEXY; ALKALINE PHOSPHATASE; ANEURYSMS; INTRACEREBRAL HEMORRHAGE; MICRORADIOGRAPHY; STROKE;
D O I
10.1097/00005072-199205000-00004
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
For over a century a controversy has existed about the prevalence and significance of Charcot-Bouchard (C-B) aneurysms, especially regarding their relationship to intracerebral hemorrhage (ICH) in man. We reassessed C-B aneurysms by staining thick brain sections from 35 hypetensives and 20 normotensives with the alkaline phosphatase (AP) endothelial stain followed by light microscopy and high-resolution microradiography. Charcot-Bouchard aneurysms were conspicuously absent in both groups which included four cases of hypertensive ICH. The three-dimensional perspective and enhanced ability to trace vessels with these techniques helped to identify arteriolar coils and twists that can be mistaken for aneurysms when demonstrated by injection methods. Routine brain pathologic sections from 2,800 autopsies over a decade showed rare examples of parenchymal aneurysms. We conclude that elimination in our study of a) injection artifacts and b) misinterpretations shows that C-B aneurysms are uncommon and have little relationship to ICH. Despite this, and in view of the original contribution of Charcot and Bouchard, the occasional examples of brain parenchymal aneurysms should continue to bear their names.
引用
收藏
页码:264 / 271
页数:8
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