CYTOCHROME-CAA3 FROM THE THERMOPHILIC BACTERIUM THERMUS-THERMOPHILUS - A MEMBER OF THE HEME-COPPER OXIDASE SUPERFAMILY

被引:26
作者
FEE, JA
YOSHIDA, T
SURERUS, KK
MATHER, MW
机构
[1] Biochemistry and Spectroscopy Group, Division of Isotope and Nuclear Chemistry, Los Alamos National Laboratory, Los Alamos, 87545, New Mexico
关键词
THERMUS CYTOCHROME-CAA3 PROTEIN SEQUENCES; METAL COORDINATION; CYANIDE BINDING; STRUCTURAL MODEL;
D O I
10.1007/BF00762852
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
The subject of this short review is the cytochrome c oxidase (caa3) from the thermophilic bacterium Thermus thermophilus. First, some of the extensive physical and enzymological results obtained with this enzyme are reviewed, and two experiments are described, involving isotope substitutions in combination with Mossbauer and ENDOR spectroscopies, which have provided novel insight into the active sites of the enzyme. Second, we summarize recent molecular genetic work showing that Thermus cytochrome caa3 is a bona fide member of the superfamily of heme-copper oxidases. Finally, we present a rough three-dimensional model and speculate about certain features of the metal-binding sites.
引用
收藏
页码:103 / 114
页数:12
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