AN EFFICIENT ASYMMETRIC-SYNTHESIS OF THE 4 STEREOISOMERS OF 3-HYDROXYLEUCINE

被引：41

作者：

SUNAZUKA, T

NAGAMITSU, T

TANAKA, H

OMURA, S

机构：

[1] KITASATO UNIV,KITASATO INST,BIOL FUNCT RES CTR,MINATO KU,TOKYO 108,JAPAN

[2] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

[3] UNIV PENN,MONELL CHEM SENSES CTR,DEPT CHEM,PHILADELPHIA,PA 19104

[4] UNIV PENN,RES STRUCT MATTER LAB,PHILADELPHIA,PA 19104

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 28期

关键词：

D O I：

10.1016/0040-4039(93)88055-N

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The four stereoisomers of 3-hydroxyleucine have been prepared in high overall yield and enantiomeric purity. Key steps include Sharpless asymmetric epoxidation, benzyl isocyanate-induced epoxide opening, and epimerization of an intermediate oxazolidinone ester.

引用

页码：4447 / 4448

页数：2

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