INHIBITION OF PROTEIN-SYNTHESIS BY THE NMDA CHANNEL BLOCKER MK-801

被引：16

作者：

CHARRIAUTMARLANGUE, C

DESSI, F

BENARI, Y

机构：

[1] INSERM U29, Laboratoire de Neurobiologie et Physiopathologie du Developpement, Paris, 75014

来源：

NEUROREPORT | 1994年 / 5卷 / 09期

关键词：

NMDA RECEPTOR; RAT HIPPOCAMPUS; CELL CULTURE; PROTEIN SYNTHESIS;

D O I：

10.1097/00001756-199405000-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MK-801 rs a selective non-competitive N-methyl-D-aspartate (NMDA) channel blocker which has been extensively used in order to determine the properties of NMDA receptors and their role in epilepsy and ischaemic cell death. We now report that MK-801 (10 mu M) inhibits [S-35]methionine incorporation into polypeptides by 45 +/- 7.5% in adult rat hippocampal slices and by 35 +/- 10% in cultured glial cells. This effect is NMDA-receptor independent since (i) only high doses of MK-801 induced such an effect and (ii) APV (50 mu M), a competitive NMDA receptor antagonist, or Mg2+ (10 mM), a NMDA channel blocker, did not reduce protein synthesis.

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页码：1110 / 1112

页数：3

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