THE FUNCTION OF KGF IN MORPHOGENESIS OF EPITHELIUM AND REEPITHELIALIZATION OF WOUNDS

被引：520

作者：

WERNER, S

SMOLA, H

LIAO, X

LONGAKER, MT

KRIEG, T

HOFSCHNEIDER, PH

WILLIAMS, LT

机构：

[1] UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143

[2] UNIV COLOGNE,DERMATOL & VENEROL KLIN,D-50931 COLOGNE,GERMANY

[3] NYU,MED CTR,INST RECONSTRUCT PLAST SURG,NEW YORK,NY 10016

来源：

SCIENCE | 1994年 / 266卷 / 5186期

关键词：

D O I：

10.1126/science.7973639

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The function of keratinocyte growth factor (KGF) in normal and wounded skin was assessed by expression of a dominant-negative KGF receptor transgene in basal keratinocytes. The skin of transgenic mice was characterized by epidermal atrophy, abnormalities in the hair follicles, and dermal hyperthickening. Upon skin injury, inhibition of KGF receptor signaling reduced the proliferation rate of epidermal keratinocytes at the wound edge, resulting in substantially delayed reepithelialization of the wound.

引用

页码：819 / 822

页数：4

共 19 条

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