REGIOSELECTIVE SCHIFF-BASE-MEDIATED DEGLYCOSIDATION OF DIGITALIS GLYCOSIDES - NEW EFFICIENT SYNTHESIS OF DIGOXIGENIN BIS-DIGITOXOSIDE AND DIGOXIGENIN MONO-DIGITOXOSIDE

被引：5

作者：

ADAMCZYK, M

GROTE, J

机构：

[1] Divisional Organic Chemistry (D9NM), Abbott Diagnostics Division, Abbott Laboratories, Abbott Park

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 01期

关键词：

D O I：

10.1016/0040-4039(94)02212-T

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dialdehydes derived from digoxin glycosides via sodium periodate oxidation were regioselectively deglycosylated by various amino acids in anhydrous methanolic solution to afford excellent yields of digoxigenin bis-digitoxoside and digoxigenin mono-digitoxoside in a single step.

引用

页码：63 / 66

页数：4

共 10 条

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[2] The chemistry of the cardiac glycosides
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[J]. CHEMICAL REVIEWS, 1935, 17 (02) : 187 - 249
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