ADAMANTANE AND NIPECOTIC ACID-DERIVATIVES AS NOVEL BETA-TURN MIMICS

被引：12

作者：

HOEKSTRA, WJ

PRESS, JB

BONNER, MP

ANDRADEGORDON, P

KEANE, PM

DURKIN, KA

LIOTTA, DC

MAYO, KH

机构：

[1] EMORY UNIV, ATLANTA, GA 30322 USA

[2] THOMAS JEFFERSON UNIV, PHILADELPHIA, PA 19107 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80362-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1,3-Adamantanediamine and nipecotic acid were used as scaffolds in designing beta-turn peptide mimetic derivatives 3 and 5, respectively, targeted as fibrinogen-GPIIB/IIA antagonists. The design focused on the 406-409 KQAG region of the gamma-chain of fibrinogen which appears as a beta-turn in solution NMR structures of Fg-gamma385-411.

引用

页码：1361 / 1364

页数：4

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