QUANTITATIVE DETERMINATION OF PHYSOSTIGMINE FROM AQUEOUS SOLUTION

被引：9

作者：

TEARE, FW

BORST, SI

机构：

[1] Faculty of Pharmacy, University of Toronto, Toronto

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1969年 / 21卷 / 05期

关键词：

D O I：

10.1111/j.2042-7158.1969.tb08249.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A gas chromatographic method is described for the direct determination of physostigmine base from a solution of physostigmine salicylate. The method involves isolation of physostigmine salicylate from an aqueous solution by a freeze drying process, subsequent conversion to a trimethylsilyl (TMS) derivative and gas liquid chromatography. The trimethylsilyl salt dissociates on injection into the flash vapourizer inlet of a gas Chromatograph, and the physostigmine‐TMS and salicylic acid‐TMS derivatives are eluted separately. Due to the specificity of the silylation reaction it is possible to determine by gas chromatography the alkaloid content in the presence of its degradation products. A modification of the method was necessary for the assay of a commercial formulation containing certain additives. 1969 Royal Pharmaceutical Society of Great Britain

引用

页码：277 / &

共 7 条

[1] GAS CHROMATOGRAPHY OF ALKALOIDS, ALKALOIDAL SALTS, AND DERIVATIVES [J].