(+/-)-4-TERT-BUTYL-3-CYANO-1-(4-ETHYNYLPHENYL)-2,6,7-TRIOXABICYCLO[2.2.2]OCTANE - SYNTHESIS OF A REMARKABLY POTENT GABAA RECEPTOR ANTAGONIST

被引：9

作者：

PALMER, CJ

COLE, LM

CASIDA, JE

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1988年 / 31卷 / 06期

关键词：

D O I：

10.1021/jm00401a002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1064 / 1066

页数：3

共 13 条

[1] FACILE SYNTHESIS OF ETHYNYLATED BENZOIC-ACID DERIVATIVES AND AROMATIC-COMPOUNDS VIA ETHYNYLTRIMETHYLSILANE [J].

AUSTIN, WB ;

BILOW, N ;

KELLEGHAN, WJ ;

LAU, KSY .

JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (11) :2280-2286

[2]

CASIDA JE, 1985, MOL PHARMACOL, V28, P246

[3] STRUCTURE ACTIVITY CORRELATIONS FOR INTERACTIONS OF BICYCLOPHOSPHORUS ESTERS AND SOME POLYCHLOROCYCLOALKANE AND PYRETHROID INSECTICIDES WITH THE BRAIN-SPECIFIC TERT-BUTYLBICYCLOPHOSPHOROTHIONATE RECEPTOR [J].

CASIDA, JE ;

LAWRENCE, LJ .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1985, 61 (SEP) :123-132

[4]

CASIDA JE, IN PRESS CHLORIDE CH

[5] POLYCHLOROCYCLOALKANE INSECTICIDE-INDUCED CONVULSIONS IN MICE IN RELATION TO DISRUPTION OF THE GABA-REGULATED CHLORIDE IONOPHORE [J].

COLE, LM ;

CASIDA, JE .

LIFE SCIENCES, 1986, 39 (20) :1855-1862

[6] A NEW GENERAL SYNTHETIC ROUTE TO BRIDGED CARBOXYLIC ORTHO ESTERS [J].

COREY, EJ ;

RAJU, N .

TETRAHEDRON LETTERS, 1983, 24 (50) :5571-5574

[7] INTERACTIONS OF LINDANE, TOXAPHENE AND CYCLODIENES WITH BRAIN-SPECIFIC TERT-BUTYLBICYCLOPHOSPHOROTHIONATE RECEPTOR [J].

LAWRENCE, LJ ;

CASIDA, JE .

LIFE SCIENCES, 1984, 35 (02) :171-178

[8]

LAWRENCE LJ, 1985, J NEUROCHEM, V45, P798, DOI 10.1111/j.1471-4159.1985.tb04063.x

[9]

OBATA T, 1988, J PHARMACOL EXP THER, V244, P802

[10] DRUG-INTERACTIONS AT THE GABA RECEPTOR-IONOPHORE COMPLEX [J].

OLSEN, RW .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1982, 22 :245-277

← 1 2 →