ABNORMALITIES OF T-CELL IMMUNOREGULATION IN HEMORRHAGIC-FEVER WITH RENAL SYNDROME

The functions of spontaneous suppressor T cells and T lymphocyte subsets in patients with hemorrhagic fever with renal syndrome were compared. In the early stages of disease, decreased activity of spontaneous suppressor T cells was concurrent with increased numbers of CD8+ cells and a reversed CD4:CD8 ratio. These changes were related to abnormalities in serum C3 level and circulating immune complexes. In the recovery stages of the illness, spontaneous suppressor T cell activity and T cell subsets returned to normal levels. © 1990 by the University of Chicago. All rights reserved.