USE OF POWDERED SOLUTIONS TO IMPROVE THE DISSOLUTION RATE OF POLYTHIAZIDE TABLETS

被引：20

作者：

SHETH, A ^{[1
]}

JAROWSKI, CI ^{[1
]}

机构：

[1] ST JOHNS UNIV,COLL PHARM & ALLIED HLTH PROFESS,JAMAICA,NY 11439

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 05期

关键词：

D O I：

10.3109/03639049009114908

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Solutions of polythiazide in polyethylene glycol 400 were admixed with microcrystalline cellulose (RC-591) and silica. The resulting free-flowing powder was incorporated into tablet formulations by direct compression. The dissolution rates of polythizizde frm these tablets were significantly more rapid than from commercially available tablets. The stability of these tablets at 40°0C and high humidity was studied. The powdered solution formulas were also compared with a polythiazide dispersion in polyethylene glycol 6000 which exhibited an equally superior dissolution profile. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：769 / 777

页数：9

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