CORRELATION BETWEEN NUCLEOLAR ORGANIZER REGION STAINING AND KI-67 IMMUNOSTAINING IN HUMAN GLIOMAS

被引：58

作者：

HARA, A ^{[1
]}

HIRAYAMA, H ^{[1
]}

SAKAI, N ^{[1
]}

YAMADA, H ^{[1
]}

TANAKA, T ^{[1
]}

MORI, H ^{[1
]}

机构：

[1] GIFU UNIV, SCH MED, DEPT PATHOL, GIFU 500, JAPAN

来源：

SURGICAL NEUROLOGY | 1990年 / 33卷 / 05期

关键词：

Glioma; Immunohistochemistry; Ki-67; Nucleolar organizer regions; Proliferating potential;

D O I：

10.1016/0090-3019(90)90199-Y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Fourteen cases of various grades of gliomas were investigated by an immunohistochemical method using a monoclonal antibody, Ki-67, which reacted with a nuclear antigen in proliferating cells, and the correlation between Ki-67 labeling index and the number of nucleolar organizer regions stained by an argyrophilic method. Four normal brain tissue samples without neoplastic cells, which were obtained at surgery, were also examined for nucleolar organizer region staining. Both the mean number of nucleolar organizer regions and the percentage of Ki-67 positive cells well reflected the histological grade of gliomas (astrocytoma grade 2: Ki-67, 0.5% and nucleolar organizer regions, 1.6; astrocytoma grade 3: Ki-67, 3% and nucleolar organizer regions, 2.5; astrocytoma grade 4: Ki-67, 5.2% and nucleolar organizer regions, 2.8). Also, the percentage of Ki-67 positive cells and the mean number of nucleolar organizer regions were found to be linearly related (r = 0.91). Both values of high-grade astrocytomas were significantly greater than those of low-grade astrocytomas (p < 0.01 and p < 0.001). Thus, the mean number of nucleolar organizer regions as well as Ki-67 labeling index reflect the proliferating potential of gliomas. © 1990.

引用

页码：320 / 324

页数：5

共 30 条

[1] PERCENTAGE OF CELLS IN THE S-PHASE OF THE CELL-CYCLE IN HUMAN LYMPHOMA DETERMINED BY FLOW-CYTOMETRY - CORRELATION WITH LABELING INDEX AND PATIENT SURVIVAL [J].