RELAXANT EFFECT OF BENZODIAZEPINES ON UTERINE RINGS ISOLATED FROM ESTROGEN-TREATED RATS

被引：10

作者：

KAZANIETZ, MG

ELGOYHEN, AB

机构：

[1] UNIV BUENOS AIRES,FAC FARM & BIOQUIM,CATEDRA FARMACOL,BUENOS AIRES,ARGENTINA

[2] CONSEJO NACL INVEST CIENT & TECN,INST INVEST FARMACOL,RA-1113 BUENOS AIRES,ARGENTINA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 185卷 / 2-3期

关键词：

Benzodiazepines (peripheral effects); PK; 11195; Ro; 5-4864; Uterine relaxation;

D O I：

10.1016/0014-2999(90)90646-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

K+-contracted rat uterine rings were relaxed in a concentration-dependent manner by the benzodiazepines Ro 5-4864, diazepam and clonazepam, as well as by the putative peripheral benzodiazepine antagonist PK 11195. The relaxation induced by diazepam was not counteracted by the central antagonist Ro 15-1788 (10 μM), and the relaxant effects of Ro 5-4864 and of diazepam were not prevented by either the GABAA antagonist bicuculline (10 μM) or the β-adrenoceptor antagonist propranolol (1 μM). The mechanism underlying the relaxant effects of benzodiazepines on K+-contracted uterine rings is still under study. © 1990.

引用

页码：231 / 234

页数：4

共 10 条

[1] BENZODIAZEPINE INHIBITION OF THE CALCIUM-CALMODULIN PROTEIN-KINASE SYSTEM IN BRAIN MEMBRANE [J].