CHRONIC COCAINE ALTERS LIMBIC EXTRACELLULAR DOPAMINE - NEUROCHEMICAL BASIS FOR ADDICTION

被引：87

作者：

IMPERATO, A

MELE, A

SCROCCO, MG

PUGLISIALLEGRA, S

机构：

[1] UNIV ROME LA SAPIENZA,IST FARMACOL MED,CATTEDRA 2,DIPARTIMENTO GENET & BIOL MOLEC,I-00185 ROME,ITALY

[2] UNIV ROME LA SAPIENZA,DIPARTIMENTO PSICOL,I-00185 ROME,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 212卷 / 2-3期

关键词：

COCAINE (CHRONIC); DOPAMINE; ADDICTION;

D O I：

10.1016/0014-2999(92)90349-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The extracellular concentration of dopamine in the ventral striatum was measured daily by means of brain microdialysis. Chronic cocaine (10 mg/kg twice daily) altered the dopamine output compared to that in vehicle-injected rats, inducing a pronounced increase in the first 3 days followed by a clear-cut decrease. This reduction in the output of dopamine during chronic cocaine as well as during withdrawal may be neurochemical substrate for the addictive properties of cocaine.

引用

页码：299 / 300

页数：2

共 5 条

[1] PROFOUND DEPRESSION OF MESOLIMBIC DOPAMINE RELEASE AFTER MORPHINE-WITHDRAWAL IN DEPENDENT RATS [J].