THE OUTER-MEMBRANE PERMEABILITY-INCREASING ACTION OF DEACYLPOLYMYXINS

被引：49

作者：

VILJANEN, P

MATSUNAGA, H

KIMURA, Y

VAARA, M

机构：

[1] UNIV HELSINKI,DEPT BACTERIOL & IMMUNOL,HAARTMANINKATU 3,SF-00290 HELSINKI 29,FINLAND

[2] MIYAZAKI UNIV,FAC AGR,DEPT FISHERIES,MIYAZAKI 88921,JAPAN

[3] MUKOGAWA WOMENS UNIV,FAC PHARMACEUT SCI,NISHINOMIYA,HYOGO 663,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 05期

关键词：

D O I：

10.7164/antibiotics.44.517

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The outer membrane permeability-increasing action of deacylpolymyxins was compared to the well-known potent action of polymyxin B nonapeptide (PMBN). Deacylpolymyxin B (DAPB), prepared by treating polymyxin B with polymyxin acylase, was found to be a slightly more effective permeabilizer than PMBN. As low a DAPB concentration as 1-mu-g/ml sensitized Escherichia coli to the probe antibiotics (rifampin, fusidic acid, erythromycin, clindamycin, novobiocin) by factors 30 approximately 100 and Salmonella typhimurium by factors 10 approximately 100. A higher concentration (3-mu-g/ml) of DAPB elicited further sensitization. Also deacylcolistin (DAC) was found to be an effective permeabilizer.

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页码：517 / 523

页数：7

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