ABROGATION OF AGE-RELATED RESISTANCE TO CHICKEN INFECTIOUS-ANEMIA BY EMBRYONAL BURSECTOMY

被引：29

作者：

HU, LB ^{[1
]}

LUCIO, B ^{[1
]}

SCHAT, KA ^{[1
]}

机构：

[1] CORNELL UNIV, COLL VET MED, DEPT AVIAN & AQUAT ANIM MED, ITHACA, NY 14853 USA

来源：

AVIAN DISEASES | 1993年 / 37卷 / 01期

关键词：

D O I：

10.2307/1591469

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Embryonally bursectomized (Ebx) chickens developed signs and lesions typical of chicken infectious anemia (CIA) when infected with CIA-1 isolate of chicken infectious anemia virus (CIAV) at 21 or 38 days of age. In both cases, the chickens had low hematocrit values after the 14th day of inoculation, and the percentage of CD4+ and CD8+ cells in the thymus was markedly reduced at 21 days postinoculation. Even though intact chickens became infected, they never developed low hematocrit values. The data support the hypothesis that age-related resistance to CIA is antibody-mediated and is not due to disappearance of the CIAV target cell; the data also suggest that CD4+/CD8+ cells are the target for infection.

引用

页码：157 / 169

页数：13

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