THE PROGRESSION ASSOCIATED ANTIGEN MUC18 - A UNIQUE MEMBER OF THE IMMUNOGLOBULIN SUPERGENE FAMILY

被引：47

作者：

JOHNSON, JP

ROTHBACHER, U

SERS, C

机构：

来源：

MELANOMA RESEARCH | 1993年 / 3卷 / 05期

关键词：

CELL ADHESION MOLECULE; IMMUNOGLOBULIN SUPERFAMILY; PROMOTER REGION; SMOOTH MUSCLE CELL ANTIGEN; TUMOR PROGRESSION ANTIGEN;

D O I：

10.1097/00008390-199310000-00006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cell surface glycoprotein MUC18 was originally identified as a progression associated antigen in melanoma. MUC18 is expressed most strongly on metastatic losions and advanced primary tumours and is only rarely detected in benign lesions. cDNA, cloning revealed MUC18 to be a novel member of the immunoglobulin superfamily with sequence similarity to a number of cell adhesion molecules. Cloning of both the human and mouse MUC18 genes indicate that their predicted protein structures are very similar with an overall amino acid identity of 75%. Like its human counterpart, murine MUC18 is also expressed by transformed melanocytes. Analysis of the promoter region of the human gene has provided evidence for regulatory elements found in smooth muscle specific genes and in both human and mouse: this is the normal site of MUC18 expression. The presence of putative binding sites for the transcriptional factors AP-1, AP-2 and CREB, suggest that MUC18 gene expression can also be modulated by external factors.

引用

页码：337 / 340

页数：4

共 22 条

[1] Clark W.H., Elder D.E., Guerry D., A study of tumor progression. The precursor lesions of superficial spreading and nodular melanoma, Human Pathol, 15, pp. 1147-1165, (1984)
[2] Johnson J.P., Stade B.G., Rothbacher U., Melanoma antigens and their association with malignant transformation and tumor progression, Ferrone S (Eds). Melanoma Antigens, Heidelberg: Springer Verlag, pp. 106-118, (1990)
[3] Lehmann J.M., Holzmann B., Breitbart E.W., Discrimination between benign and malignant cells of melanocytic lineage by two novel antigens, a glycoprotein with a molecular weight of 113,000 and a protein with a molecular weight of 76,000, Cancer Res, 47, pp. 841-845, (1987)
[4] Holzmann B., Brocker E.B., Lehmann J.M., Tumor progression in human melanoma: Five stages defined by their antigenic phenotypes, Int J Cancer, 39, pp. 466-471, (1987)
[5] Luca M., Hunt B., Bucana C.D., Direct correlation between MUC18 expression and metastatic potential of human melanoma cells, Melanoma Res, 3, pp. 35-41, (1993)
[6] Lehmann J.M., Riethmiiller G., Johnson J.P., MUC18, a marker of tumor progression in human melanoma shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily, Proc Natl Acad Set USA, 86, pp. 9891-9895, (1989)
[7] Fearon E.R., Cho K.R., Nigro J.M., Identification of a chromosome 18q gene that is altered in colorectal cancers, Science, 247, pp. 49-56, (1990)
[8] Thompson J.A., Grunert F., Zimmermann W., Carcinoem-bryonic antigen gene family: Molecular biology and clinical perspectives, J Clin Lab Anal, 5, pp. 344-366, (1991)
[9] Edelman G.M., Crossin K.L., Cell adhesion molecules: Implications for a molecular histology, Ann Rev Biochem, 60, pp. 155-190, (1991)
[10] Tanaka H., Matsui T., Agata T., Molecular cloning and expression of a novel adhesion molecule, SCI, Neuron, 7, pp. 535-545, (1991)

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