EFFECT OF NIMODIPINE, DILTIAZEM AND BAY K-8644 ON THE BEHAVIORAL AND NEUROCHEMICAL CHANGES ASSOCIATED WITH NALOXONE-PRECIPITATED WITHDRAWAL IN THE RAT - A COMPARISON WITH CLONIDINE

被引：13

作者：

COLADO, MI

ALFARO, MJ

LOPEZ, F

DELVAL, V

MARTIN, MI

机构：

来源：

GENERAL PHARMACOLOGY | 1993年 / 24卷 / 01期

关键词：

D O I：

10.1016/0306-3623(93)90008-L

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Nimodipine, diltiazem and BAY K 8644 decreased the incidence of wet dog shakes, teeth chattering, grooming and diarrhoea to a similar degree as clonidine. 2. Nimodipine, diltiazem and BAY K 8644 had no effect on changes in the serotonin metabolism induced by naloxone precipitated abstinence syndrome. 3. Clonidine decreased the ratio of serotonin turnover in the brain of morphine-dependent rats. 4. From these experiments it is concluded that nimodipine, diltiazem and BAY K 8644 exert their effects in preventing morphine withdrawal symptoms through a mechanism independent of the serotonergic system.

引用

页码：35 / 41

页数：7

共 42 条

[1] EFFECTS OF PERIPHERAL AND CENTRAL ADMINISTRATION OF CALCIUM-CHANNEL BLOCKERS IN THE NALOXONE-PRECIPITATED ABSTINENCE SYNDROME IN MORPHINE-DEPENDENT RATS [J].