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SPECTROPHOTOMETRIC DETERMINATION OF DICLOFENAC SODIUM VIA OXIDATION REACTIONS

被引：32
作者：
KAMATH, BV
SHIVRAM, K
机构：
[1] Department of Chemistry, Faculty of Science, M.S. University of Baroda
来源：
ANALYTICAL LETTERS | 1993年 / 26卷 / 05期
关键词：
SPECTROPHOTOMETRY; DICLOFENAC DETERMINATION; DRUG FORMULATION;
D O I：
10.1080/00032719308019873
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Simple spectrophotometric methods are described for the determination of diclofenac sodium in pharmaceutical preparations. The methods are based on the oxidation of the drug using reagents viz. ceric ammonium sulphate, dibromodimethylhydantoin, N-bromosuccinimide, and potassium bromate to yield coloured products with maximum absorbance at 450, 385, 385 and 495 nm and linear calibration graphs in the range of 2 - 16, 40 - 400, 50 - 500 and 50 - 600 mug.ml-1 respectively. The methods are statistically validated and found to be accurate, sensitive and reproducible.
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页码：903 / 911
页数：9
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