DETECTION OF ALUMINUM(III) BINDING TO CITRATE IN HUMAN BLOOD-PLASMA BY PROTON NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY

被引：36

作者：

BELL, JD

KUBAL, G

RADULOVIC, S

SADLER, PJ

TUCKER, A

机构：

[1] UNIV LONDON, BIRKBECK COLL,DEPT CHEM,GORDON HOUSE,29 GORDON SQ, LONDON WC1H 0PP, ENGLAND

[2] CHRISTOPHER INGOLD LABS, LONDON WC1H 0PP, ENGLAND

[3] HAMMERSMITH HOSP, NMR UNIT, LONDON W12 0HS, ENGLAND

来源：

ANALYST | 1993年 / 118卷 / 03期

关键词：

PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ALUMINUM; CITRATE; DESFERRIOXAMINE; BLOOD PLASMA;

D O I：

10.1039/an9931800241

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Reactions of Al3+ (50-500 mumol l-1) with intact blood plasma and its low relative molecular mass ultrafiltrate (<5 kDa) have been studied by proton nuclear magnetic resonance spectroscopy. Binding to citrate was detected and was reversed by addition of desferrioxamine. The use of combined exponential and sine-bell functions for the resolution enhancement of spectra of plasma is illustrated.

引用

页码：241 / 244

页数：4

共 35 条

[1]

Bell J D, 1989, NMR Biomed, V2, P246, DOI 10.1002/nbm.1940020513

[2]

BELL JD, 1988, CHEM BRIT, V24, P1021

[3] ASSIGNMENT OF RESONANCES FOR ACUTE-PHASE GLYCOPROTEINS IN HIGH-RESOLUTION PROTON NMR-SPECTRA OF HUMAN-BLOOD PLASMA [J].