LIPASE-CATALYZED DIACYLATION OF 1,3-BUTANEDIOL

被引：10

作者：

EGUCHI, T

MOCHIDA, K

机构：

[1] Tokyo Research Laboratories, Kyowa Hakko Kogyo Co. Ltd., Tokyo, 194, Machida

来源：

BIOTECHNOLOGY LETTERS | 1993年 / 15卷 / 09期

关键词：

D O I：

10.1007/BF00131763

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A kinetic resolution of 1,3-butanediol was accomplished by lipase-catalyzed enantioselective diacylations in organic solvent. Diacylation of 1,3-butanediol was carried out using immobilized lipase SP382 (from Candida sp.) to produce (R) -1,3-diacetoxybutane with 85.8% e.e.. And then, this optically active product was chemically hydrolyzed to diol, and re-acylated with lipase SP382 to (R) -1,3-diacetoxybutane with over 98% e.e..

引用

收藏

页码：955 / 960

页数：6

相关论文

共 19 条

[1] AN ASYMMETRIC-SYNTHESIS OF ALPHA-BENZYLOXY ALDEHYDES HAVING A CHIRAL TERTIARY CENTER - AN APPLICATION TO THE ASYMMETRIC-SYNTHESIS OF EXO-(+)-BREVICOMIN [J].

ASAMI, M ;

MUKAIYAMA, T .

CHEMISTRY LETTERS, 1983, (01) :93-96

[2] QUANTITATIVE-ANALYSES OF BIOCHEMICAL KINETIC RESOLUTIONS OF ENANTIOMERS [J].

CHEN, CS ;

FUJIMOTO, Y ;

GIRDAUKAS, G ;

SIH, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (25) :7294-7299

[3]

EGUCHI T, 1993, UNPUB

[4]

Ferrelra J.T.B., 1990, TETRAHEDRON, V46, P6311

[5] SYNTHESIS OF (RECIFEIOLIDE) (R)-TRANS-11-HYDROXY-8-DODECENOIC ACID LACTONE [J].

GERLACH, H ;

OERTLE, K ;

THALMANN, A .

HELVETICA CHIMICA ACTA, 1976, 59 (03) :755-760

[6] ENZYMATIC PREPARATION OF ENANTIOMERICALLY PURE AND SELECTIVELY PROTECTED 1,2-DIOLS AND 1,3-DIOLS [J].

GOERGENS, U ;

SCHNEIDER, MP .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (16) :1066-1068

[7] RESOLUTION OF 1,3-ALKANEDIOLS VIA CHIRAL SPIROKETALS DERIVED FROM L-MENTHONE [J].

HARADA, T ;

KUROKAWA, H ;

OKU, A .

TETRAHEDRON LETTERS, 1987, 28 (41) :4843-4846

[8] ACCESS TO (S)-2-METHYLOXETANE AND THE PRECURSOR (S)-1,3-BUTANEDIOL OF HIGH ENANTIOMERIC PURITY [J].

HINTZER, K ;

KOPPENHOEFER, B ;

SCHURIG, V .

JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (20) :3850-3854

[9] SYNTHESIS OF OPTICALLY-ACTIVE 25-METHYL-1.6-DIOXA-SPIRO[4.5]DECANE AND 7S-METHYL-1.6-DIOXA-SPIRO[4.5]DECANE, THE PHEROMONE COMPONENTS OF PARAVESPULA-VULGARIS (L), FROM S-ETHYL LACTATE [J].

HINTZER, K ;

WEBER, R ;

SCHURIG, V .

TETRAHEDRON LETTERS, 1981, 22 (01) :55-58

[10]

HOFFMANN RW, 1987, LIEBIGS ANN CHEM, P977