IMPAIRED DRUG UPTAKE IN METHOTREXATE RESISTANT CRITHIDIA-FASCICULATA WITHOUT CHANGES IN DIHYDROFOLATE-REDUCTASE ACTIVITY OR GENE AMPLIFICATION

被引：29

作者：

DEWES, H ^{[1
]}

OSTERGAARD, HL ^{[1
]}

SIMPSON, L ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1986年 / 19卷 / 02期

关键词：

D O I：

10.1016/0166-6851(86)90120-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：149 / 161

页数：13

共 45 条

[1]

ALT FW, 1978, J BIOL CHEM, V253, P1357

[2]

ALT FW, 1976, J BIOL CHEM, V251, P3063

[3] PURIFICATION AND PROPERTIES OF ESCHERICHIA-COLI DIHYDROFOLATE-REDUCTASE [J].

BACCANARI, D ;

PHILLIPS, A ;

SMITH, S ;

SINSKI, D ;

BURCHALL, J .

BIOCHEMISTRY, 1975, 14 (24) :5267-5273

[4] DRUG-RESISTANT LEPTOMONAS - CROSS-RESISTANCE IN TRYPANOCIDE-RESISTANT CLONES [J].

BACCHI, CJ ;

LAMBROS, C ;

ELLENBOGEN, BB ;

PENKOVSKY, LN ;

SULLIVAN, W ;

EYINNA, EE ;

HUTNER, SH .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1975, 8 (06) :688-692

[5] UNSTABLE DNA AMPLIFICATIONS IN METHOTREXATE-RESISTANT LEISHMANIA CONSIST OF EXTRACHROMOSOMAL CIRCLES WHICH RELOCALIZE DURING STABILIZATION [J].

BEVERLEY, SM ;

CODERRE, JA ;

SANTI, DV ;

SCHIMKE, RT .

CELL, 1984, 38 (02) :431-439

[6]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[7]

Browning C. H., 1954, Annals of the New York Academy of Sciences, V59, P198, DOI 10.1111/j.1749-6632.1954.tb45932.x

[8] OVERPRODUCTION OF A BIFUNCTIONAL THYMIDYLATE SYNTHETASE-DIHYDROFOLATE REDUCTASE AND DNA AMPLIFICATION IN METHOTREXATE-RESISTANT LEISHMANIA-TROPICA [J].

CODERRE, JA ;

BEVERLEY, SM ;

SCHIMKE, RT ;

SANTI, DV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (08) :2132-2136

[9]

COWAN KH, 1984, J BIOL CHEM, V259, P793

[10] ACTIVE TRANSPORT OF AMINOPTERIN IN YOSHIDA SARCOMA CELLS [J].

DIVEKAR, AY ;

VAIDYA, NR ;

BRAGANCA, BM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1967, 135 (05) :927-+

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