EFFECT OF FOOD ON ABSORPTION OF ERYTHROMYCIN - STUDY OF 2 DERIVATIVES, THE STEARATE AND THE BASE

被引:31
作者
MALMBORG, AS
机构
[1] Department of Clinical Microbiology, Huddinge Hospital
关键词
D O I
10.1093/jac/5.5.591
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Two derivatives of erythromycin, the stearate and the enteric-coated base have been given in a cross-over study to both fasting and non-fasting volunteers. The stearate gave higher plasma concentrations in non-fasting than in fasting subjects. The area under the curve was significantly larger during steady state day 7 than after a single dose. The base showed larger individual variations in concentrations The release of the drug from the enteric-coated tablets was depressed by food, but the absorption was not prevented. © 1979, by The British Society for Antimicrobial Chemotherapy.
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页码:591 / 599
页数:9
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