METASTASIS AND ANGIOGENESIS

被引:58
作者
MAHADEVAN, V
HART, IR
机构
[1] Biology of Metastasis Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, England
关键词
Angiogenesis; Angiogenic factors; Metastasis; Neo-vascularisation; Tumour vasculature;
D O I
10.3109/02841869009089997
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The relationship of angiogenesis, the growth of new blood vessels, to the process of tumour metastasis is examined. While the occurrence of angiogenesis generally is a necessary prerequisite for the formation of secondary tumours its presence is not a guarantee that cancer dissemination will occur. Novel approaches to antimetastatic therapy, using the newly formed vascular bed of tumours as the target, have produced successful results in experimental animals though such approaches have yet to be undertaken in the clinic. ©1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
引用
收藏
页码:97 / 103
页数:7
相关论文
共 47 条
[1]  
Algire GH, 1943, J NATL CANCER I, V4, P1
[2]   VASCULAR REACTIONS OF NORMAL AND MALIGNANT TISSUES INVIVO .1. VASCULAR REACTIONS OF MICE TO WOUNDS AND TO NORMAL AND NEOPLASTIC TRANSPLANTS [J].
ALGIRE, GH ;
CHALKLEY, HW .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1945, 6 (01) :73-85
[3]   MIGRATION AND PROLIFERATION OF ENDOTHELIAL CELLS IN PREFORMED AND NEWLY FORMED BLOOD-VESSELS DURING TUMOR ANGIOGENESIS [J].
AUSPRUNK, DH ;
FOLKMAN, J .
MICROVASCULAR RESEARCH, 1977, 14 (01) :53-65
[4]   MAST-CELLS AND MATRIX DEGRADATION AT SITES OF TUMOR INVASION IN RAT MAMMARY ADENOCARCINOMA [J].
DABBOUS, MK ;
WALKER, R ;
HANEY, L ;
CARTER, LM ;
NICOLSON, GL ;
WOOLLEY, DE .
BRITISH JOURNAL OF CANCER, 1986, 54 (03) :459-465
[5]  
DVORAK HF, 1986, NEW ENGL J MED, V315, P1650
[6]  
DVORAK HF, 1988, AM J PATHOL, V133, P95
[7]  
Fidler I J, 1978, Adv Cancer Res, V28, P149, DOI 10.1016/S0065-230X(08)60648-X
[8]   ANGIOGENESIS INHIBITION AND TUMOR-REGRESSION CAUSED BY HEPARIN OR A HEPARIN FRAGMENT IN THE PRESENCE OF CORTISONE [J].
FOLKMAN, J ;
LANGER, R ;
LINHARDT, RJ ;
HAUDENSCHILD, C ;
TAYLOR, S .
SCIENCE, 1983, 221 (4612) :719-725
[9]   INDUCTION OF ANGIOGENESIS DURING THE TRANSITION FROM HYPERPLASIA TO NEOPLASIA [J].
FOLKMAN, J ;
WATSON, K ;
INGBER, D ;
HANAHAN, D .
NATURE, 1989, 339 (6219) :58-61
[10]   ANGIOGENIC FACTORS [J].
FOLKMAN, J ;
KLAGSBRUN, M .
SCIENCE, 1987, 235 (4787) :442-447