DESIGN OF ALPHA-ALKYL BETA-HYDROXY ESTERS SUITABLE FOR PROVIDING OPTICAL RESOLUTION BY LIPASE HYDROLYSIS

被引：35

作者：

ITOH, T

KURODA, K

TOMOSADA, M

TAKAGI, Y

机构：

[1] Department of Chemistry, Faculty of Education, Okayama University

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 02期

关键词：

D O I：

10.1021/jo00002a054

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A study of the lipase-catalyzed hydrolyses of various alpha-substituted beta-acetoxy esters revealed that a sulfur functional group in the ester, which could play an important role in the stereorecognition by lipase A6 (Aspergillus sp.) and an anti conformation in the ester, promotes satisfactory results in the hydrolysis.

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页码：797 / 804

页数：8

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