EFFECT OF MORPHINE APPLIED LOCALLY TO MESENCEPHALIC DOPAMINE CELL-BODIES ON SPONTANEOUS MOTOR-ACTIVITY IN THE RAT

被引：324

作者：

JOYCE, EM

IVERSEN, SD

机构：

[1] The Psychological Laboratory, University of Cambridge, Cambridge, Downing Street

来源：

NEUROSCIENCE LETTERS | 1979年 / 14卷 / 2-3期

关键词：

D O I：

10.1016/0304-3940(79)96149-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of local application of morphine (5 μg) into the ventral tegmental area (VTA) or substantia nigra, pars compacta (SNc) on spontaneous activity was studied in the rat. Morphine in the VTA but not SNc produced an enhancement of locomotor activity which became progressively augmented with repeated injections. This effect could be blocked by systemic injections of naloxone or haloperidol. It is suggested that stimulation of opiate receptors in the vicinity of dopamine cell bodies can increase the activity of ascending mesencephalic dopamine neurones. © 1979.

引用

页码：207 / 212

页数：6

共 27 条

[1] TIME-DOSE RELATIONSHIPS FOR LOCOMOTOR ACTIVITY EFFECTS OF MORPHINE AFTER ACUTE OR REPEATED TREATMENT [J].