THE EFFECT OF ATP-SENSITIVE K+ CHANNELS ON THE ELECTRICAL BURST ACTIVITY AND INSULIN-SECRETION IN PANCREATIC BETA-CELLS

被引：10

作者：

CHAY, TR ^{[1
]}

KIM, JR ^{[1
]}

COOK, DL ^{[1
]}

机构：

[1] VET ADM MED CTR,DIV METAB,SEATTLE,WA 98108

来源：

CELL BIOPHYSICS | 1990年 / 17卷 / 01期

关键词：

ATP-sensitive K[!sup]+[!/sup] channels; bursting; dose-response curves to [ATP] and[ADP; intracellular Ca[!sup]2+[!/sup] ions; Mathematical modeling;

D O I：

10.1007/BF02989802

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

In recent years, the electrical burst activity of the insulin releasing pancreatic β-cells has attracted many experimentalists and theoreticians, largely because of its functional importance, but also because of the nonlinear nature of the burst activity. The ATP-sensitive K+ channels are believed to play an important role in electrical activity and insulin release. In this paper, we show by computer simulation how ATP and antidiabetic drugs can lengthen the plateau fraction of bursting and how these chemicals can increase the intracellular Ca2+ level in the pancreatic β-cell. © 1990 Humana Press Inc.

引用

页码：11 / 36

页数：26

共 50 条

[1]

ARKHAMMAR P, 1987, J BIOL CHEM, V262, P5448

[2]

Ashcroft F M, 1986, Adv Exp Med Biol, V211, P53

[3] GLUCOSE INDUCES CLOSURE OF SINGLE POTASSIUM CHANNELS IN ISOLATED RAT PANCREATIC BETA-CELLS [J].