INHIBITORS OF SKIN-TUMOR PROMOTION .8. INHIBITORY EFFECTS OF EUGLOBALS AND THEIR RELATED-COMPOUNDS ON EPSTEIN-BARR-VIRUS ACTIVATION

被引：82

作者：

TAKASAKI, M

KONOSHIMA, T

FUJITANI, K

YOSHIDA, S

NISHIMURA, H

TOKUDA, H

NISHINO, H

IWASHIMA, A

KOZUKA, M

机构：

[1] KYOTO PHARMACEUT UNIV, 5 NAKAUCHI CHO, YAMASHINA KU, KYOTO 607, JAPAN

[2] INST PHYS & CHEM RES, WAKO, SAITAMA 35101, JAPAN

[3] HOKKAIDO TOKAI UNIV, SCH ENGN, DEPT BIOSCI & TECHNOL, SAPPORO 005, JAPAN

[4] KYOTO PREFECTURAL UNIV MED, DEPT BIOCHEM, KAMIKYO KU, KYOTO 602, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 10期

关键词：

acylphloroglucinol; anti-tumor-promoter; Epstein-Barr virus; Eucalyptus globulus; euglobal; monoterpenoid; sesquiterpenoid; structural requirement; TPA;

D O I：

10.1248/cpb.38.2737

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Twelve euglobals from Eucalyptus globulus and their twenty-six related compounds were examined for their inhibitory effects on Epstein-Barr virus activation by a short-term in vitro assay. The results showed that most of the euglobals having monoterpene structures, and euglobal-III (8) had strong inhibitory activity. Grandinol (18), homograndinols (19 and 20), and compounds 26, 27, 28, and 32 showed stronger inhibitory effects. Based on the results, the structural requirements for the activity of these compounds were discussed. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：2737 / 2739

页数：3

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