VENOUS MYOGENIC TONE - STUDIES IN HUMAN AND CANINE VESSELS

被引:47
作者
BERCZI, V
GREENE, AS
DORNYEI, G
CSENGODY, J
HODI, G
KADAR, A
MONOS, E
机构
[1] SEMMELWEIS UNIV,SCH MED,INST PHYSIOL 2,H-1446 BUDAPEST,HUNGARY
[2] SEMMELWEIS UNIV,SCH MED,INST PATHOL 2,H-1446 BUDAPEST,HUNGARY
[3] E WEIL CTY HOSP,DEPT SURG,H-1446 BUDAPEST,HUNGARY
[4] MED COLL WISCONSIN,DEPT PHYSIOL,MILWAUKEE,WI 53226
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1992年 / 263卷 / 02期
关键词
VEIN; SAPHENOUS; FEMORAL; CALCIUM; CAPACITY; CAPACITANCE; BIOMECHANICS; AUTOREGULATION;
D O I
10.1152/ajpheart.1992.263.2.H315
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Active and passive mechanical properties of human saphenous and canine femoral and saphenous vein segments were measured in vitro to assess the degree of pressure-dependent venous myogenic tone (% change in diameter, physiological saline solution vs. Ca2+-free solution) in these vessels. Stepwise elevation of intraluminal pressure from 2 to 20 mmHg caused an active myogenic response, which was calcium dependent. Side branches of human saphenous veins (OD at 20 mmHg: 1.92 +/- 0.15 mm control; 2.41 +/- 0.18 mm relaxed) displayed a larger degree of myogenic tone (approximately 25%) compared with dog saphenous (OD: 2.84 +/- 0.16 mm control; 2.89 +/- 0.16 mm relaxed) and femoral (OD: 3.56 +/- 0.32 control; 3.66 +/-0.31 mm relaxed) veins (2-3%). This alteration in myogenic tone results in over 120% change in lumen capacity for the human saphenous vein, whereas for the dog saphenous and femoral veins, the change in lumen capacity is <10%. The vessels showed a constriction to norepinephrine as well as a reversible dilation to Ca2+-free perfusion. These results support the hypothesis that an active myogenic response may play an important role in the regulation of vascular capacity in the human saphenous vein, which is subject to substantial pressure variations due to changing orthostatic loads.
引用
收藏
页码:H315 / H320
页数:6
相关论文
共 25 条
[1]   DECREASED VASCULAR CONTRACTION AND ELASTIC STIFFENING AFTER INTRAMURAL LYMPHOSTASIS [J].
BERCZI, V ;
SOLTI, F ;
SCHNEIDER, F ;
MONOS, E .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (06) :H1289-H1294
[2]   VASCULAR MYOGENIC OR STRETCH-DEPENDENT TONE [J].
BEVAN, JA .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1985, 7 :S129-S136
[3]  
BOCKING JK, 1974, CAN J PHYSIOL PHARM, V52, P148, DOI 10.1139/y74-021
[4]  
COWLEY AW, 1989, NEWS PHYSIOL SCI, V4, P219
[5]  
DESPOPULUS A, 1986, COLOR ATLAS PHYSL
[6]  
Goedhard W J, 1973, Acta Cardiol, V28, P415
[7]   CHANGES IN CANINE CARDIAC-FUNCTION AND VENOUS RETURN CURVES BY THE CAROTID BAROREFLEX [J].
GREENE, AS ;
SHOUKAS, AA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 251 (02) :H288-H296
[8]   PRESSURE-INDUCED MYOGENIC ACTIVATION OF CAT CEREBRAL-ARTERIES IS DEPENDENT ON INTACT ENDOTHELIUM [J].
HARDER, DR .
CIRCULATION RESEARCH, 1987, 60 (01) :102-107
[9]   PRESSURE-DEPENDENT MEMBRANE DEPOLARIZATION IN CAT MIDDLE CEREBRAL-ARTERY [J].
HARDER, DR .
CIRCULATION RESEARCH, 1984, 55 (02) :197-202
[10]  
Honig C, 1981, MODERN CARDIOVASCULA