RESISTANCE TO COLLAGEN-INDUCED ARTHRITIS IN BIOZZI MICE IS NOT ASSOCIATED WITH A DEFECT IN AUTOANTIBODIES TO ACCESSIBLE EPITOPES ON CARTILAGE COLLAGEN

被引：1

作者：

BOUVET, JP

FRANC, B

ZYAD, A

COUDERC, J

机构：

[1] UNIV PARIS 05,HOP AMBROISE PARE,ANAT PATHOL LAB,F-75270 PARIS 06,FRANCE

[2] INST CURIE,CNRS,URA 1413,UNITE IMMUNOGENET,F-75231 PARIS 05,FRANCE

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1992年 / 35卷 / 06期

关键词：

D O I：

10.1111/j.1365-3083.1992.tb02974.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In order to understand why most strains of Biozzi mice are unexpectedly either arthritis-resistant, or susceptible, we investigate the autoantibody reactivity against matrix-embedded collagen molecules. We show a close correlation between these tissular and the free collagen antibodies, irrespective of arthritis susceptibility. These results are against an antibody response restricted to hidden non-pathogenic epitopes in the resistant mice.

引用

页码：677 / 680

页数：4

共 17 条

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