ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL STUDIES OF WHARTONS JELLY UMBILICAL-CORD CELLS

被引:97
作者
TAKECHI, K
KUWABARA, Y
MIZUNO, M
机构
[1] Department of Obstetrics and Gynecology, University of Tokyo, Bunkyo-ku, Tokyo, 113
关键词
D O I
10.1016/S0143-4004(05)80264-4
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In order to determine the significance of Wharton's jelly, the characteristics of these cells were examined by means of electron microscopy and immunohistochemistry. These cells possessed ultrastructural characteristics of both fibroblasts and smooth muscle cells, indicating that they are modified, rather than typical fibroblasts. Immunohistochemically these ‘myofibroblasts’ stained positive for actin, non-muscle myosin, vimentin and desmin. Staining for muscle myosin was negative, supporting the ultrastructural findings. As our results indicate that these cells can function in both fibrogenesis and cell contraction, we speculate that they may contribute to the elasticity of Wharton's jelly, by synthesizing collagen fibers, and participate in the regulation of umbilical blood flow by virtue of their contractile properties. © 1993, Baillière Tindall. All rights reserved.
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页码:235 / 245
页数:11
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