GRAFT-DERIVED ANTI-HPA-2B PRODUCTION AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION

被引：18

作者：

TAANING, E

JACOBSEN, N

MORLING, N

机构：

[1] STATE UNIV HOSP COPENHAGEN,RIGSHOSP,DEPT HAEMATOL,COPENHAGEN,DENMARK

[2] UNIV COPENHAGEN,INST FORENS GENET,COPENHAGEN,DENMARK

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1994年 / 86卷 / 03期

关键词：

GRAFT-DERIVED ANTI-HPA-2B; BONE MARROW TRANSPLANTATION; REFRACTORINESS;

D O I：

10.1111/j.1365-2141.1994.tb04801.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report on a male who received a bone-marrow allograft from his HLA identical sister for acute myelogenous leukaemia. After transplantation, the patient suffered from refractoriness to the transfusions of HLA-matched platelets and a strong platelet-specific antibody, anti-HPA-2b, of IgG1 subclass was demonstrated in the patient's serum. In the serum of the bone-marrow donor a weak IgG1 anti-HPA-2b was demonstrated. IgG allotyping of the patient and donor showed identical results. We could not determine the origin of the anti-HPA-2b, although we hypothesize that the anti-HPA-2b was produced by immunocompetent donor lymphocytes infused with the suspension of bone-marrow cells.

引用

页码：651 / 653

页数：3

共 11 条

[1]

BORNE AEG, 1990, BRIT J HAEMATOL, V74, P239

[2]

KIEFEL V, 1987, BLOOD, V70, P1722

[3] NH2-TERMINAL GLOBULAR DOMAIN OF HUMAN PLATELET GLYCOPROTEIN IB-ALPHA HAS A METHIONINE145/THREONINE145 AMINO-ACID POLYMORPHISM, WHICH IS ASSOCIATED WITH THE HPA-2 (KO) ALLOANTIGENS [J].