FAILURE OF GLUCOSE TO ELICIT A NORMAL SECRETORY RESPONSE IN FETAL PANCREATIC BETA-CELLS RESULTS FROM GLUCOSE INSENSITIVITY OF THE ATP-REGULATED K+ CHANNELS

被引:112
作者
RORSMAN, P
ARKHAMMAR, P
BOKVIST, K
HELLERSTROM, C
NILSSON, T
WELSH, M
WELSH, N
BERGGREN, PO
机构
[1] UNIV UPPSALA,DEPT MED CELL BIOL,S-75123 UPPSALA,SWEDEN
[2] KAROLINSKA INST,KAROLINSKA INST,DEPT ENDOCRINOL,S-10401 STOCKHOLM 60,SWEDEN
关键词
D O I
10.1073/pnas.86.12.4505
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:4505 / 4509
页数:5
相关论文
共 42 条
[1]   DIRECT MEASUREMENTS OF INCREASED FREE CYTOPLASMIC CA-2+ IN MOUSE PANCREATIC BETA-CELLS FOLLOWING STIMULATION BY HYPOGLYCEMIC SULFONYLUREAS [J].
ABRAHAMSSON, H ;
BERGGREN, PO ;
RORSMAN, P .
FEBS LETTERS, 1985, 190 (01) :21-24
[2]  
ARKHAMMAR P, 1987, J BIOL CHEM, V262, P5448
[3]   GLUCOSE INDUCES CLOSURE OF SINGLE POTASSIUM CHANNELS IN ISOLATED RAT PANCREATIC BETA-CELLS [J].
ASHCROFT, FM ;
HARRISON, DE ;
ASHCROFT, SJH .
NATURE, 1984, 312 (5993) :446-448
[4]   PHOSPHATE-METABOLISM AND GLUCOSE-INITIATED EFFLUX OF PHOSPHATE IONS IN ISLETS OF FETAL PANCREAS [J].
ASPLUND, K ;
FREINKEL, N .
DIABETES, 1978, 27 (06) :611-619
[5]   DYNAMICS OF INSULIN RELEASE FROM FETAL AND NEONATAL RAT PANCREAS [J].
ASPLUND, K .
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1973, 3 (04) :338-344
[6]   EFFECTS OF INTERMITTENT GLUCOSE INFUSIONS IN PREGNANT RATS ON FUNCTIONAL DEVELOPMENT OF FETAL PANCREATIC B-CELLS [J].
ASPLUND, K .
JOURNAL OF ENDOCRINOLOGY, 1973, 59 (02) :285-293
[7]   GLUCOSE STIMULATION OF INSULIN SECRETION FROM ISOLATED PANCREAS OF FOETAL AND NEWBORN RATS [J].
ASPLUND, K ;
WESTMAN, S ;
HELLERSTROM, C .
DIABETOLOGIA, 1969, 5 (04) :260-+
[8]  
BOKVIST K, 1988, DIABETOLOGIA, V31, P473
[9]   INTRACELLULAR ATP DIRECTLY BLOCKS K+ CHANNELS IN PANCREATIC B-CELLS [J].
COOK, DL ;
HALES, CN .
NATURE, 1984, 311 (5983) :271-273
[10]   INTRACELLULAR ADP ACTIVATES K+ CHANNELS THAT ARE INHIBITED BY ATP IN AN INSULIN-SECRETING CELL-LINE [J].
DUNNE, MJ ;
PETERSEN, OH .
FEBS LETTERS, 1986, 208 (01) :59-62