EXPRESSION PATTERN OF ACIDIC AND BASIC FIBROBLAST GROWTH-FACTOR GENES IN ADULT-RAT EYES

被引：102

作者：

NOJI, S

MATSUO, T

KOYAMA, E

YAMAAI, T

NOHNO, T

MATSUO, N

TANIGUCHI, S

机构：

[1] OKAYAMA UNIV, SCH DENT,DEPT BIOCHEM,2-5-1 SHIKATA CHO, OKAYAMA 700, JAPAN

[2] OKAYAMA UNIV, SCH MED,DEPT OPHTHALMOL, OKAYAMA 700, JAPAN

[3] KAWASAKI MED SCH, KURASHIKI, OKAYAMA 70101, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 168卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91714-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although the retinal angiogenic and mitogenic factors have been identified to be acidic and basic fibroblast growth factors (aFGF and bFGF), little information has so far been available about the cells producing them and their function in retinal tissues. We found, by in situ hybridization, that the expression pattern of the aFGF gene differed remarkably from that of the bFGF gene in adult rat eyes. Our results demonstrated that the aFGF gene was produced by photoreceptor visual cells, neuronal cells in the inner nuclear layer and ganglion cells of the retina, in addition to pigment epithelial cells of the choroid, iris and ciliary body, and epithelial cells of the cornea, conjunctiva and lens, while bFGF was synthesized solely by the photoreceptor visual cells. © 1990.

引用

页码：343 / 349

页数：7

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