Y-CHROMOSOME LOSS IN CHILDHOOD LEUKEMIAS

被引:10
作者
PADREMENDOZA, T
FARNES, P
BARKER, BE
SMITH, PS
FORMAN, EN
机构
[1] BROWN UNIV,PROVIDENCE,RI 02912
[2] RHODE ISL HOSP,DEPT ONCOL,PROVIDENCE,RI 02902
[3] RHODE ISL HOSP,DEPT PEDIAT,PROVIDENCE,RI 02902
关键词
D O I
10.1111/j.1365-2141.1979.tb03679.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Summary. During the past 3½ years cytogenetic studies have been performed on all children with leukaemia prior to treatment. Loss of the Y chromosome documented by chromosome banding techniques, was observed in bone marrow blast cells from two of 11 consecutive male children. One patient had acute myeloblastic leukaemia of t(8;21) type. The other patient was diagnosed as acute lymphoblastic leukaemia. Our studies provide evidence that Y loss occurs in childhood leukaemias and is not necessarily related to an ageing process as suggested by others. Furthermore, this study demonstrates that Y loss can occur as a sole abnormality in non‐myeloid leukaemia. Copyright © 1979, Wiley Blackwell. All rights reserved
引用
收藏
页码:43 / 48
页数:6
相关论文
共 36 条
[1]  
BARKA T, 1963, HISTOCHEMISTRY THEOR, P73
[2]   DIFFERENTIAL CELL-DIVISION IN HUMAN X-CHROMOSOME MOSAICS [J].
BARLOW, PW .
HUMANGENETIK, 1972, 14 (02) :122-&
[3]  
BRANDT L, 1976, SCAND J HAEMATOL, V16, P321
[4]  
CASPERSSON T, 1970, CHROMOSOMA, V30, P215
[5]  
FORMAN EN, 1977, BLOOD, V49, P549
[6]  
GARSON MO, 1972, SCAND J HAEMATOL, V9, P186
[7]   MISSING Y-CHROMOSOME IN JUVENILE CHRONIC MYELOGENOUS LEUKEMIA [J].
HAYS, T ;
HUMBERT, JR ;
PEAKMAN, DC ;
HUTTER, JJ ;
MORSE, HG ;
ROBINSON, A ;
AUGUST, CS .
HUMANGENETIK, 1975, 29 (03) :259-264
[8]   PH1-NEGATIVE CHRONIC MYELOCYTIC-LEUKEMIA WITH A MISSING Y-CHROMOSOME [J].
HOSSFELD, DK ;
WENDEHORST, E .
ACTA HAEMATOLOGICA, 1974, 52 (04) :232-237
[9]  
HURDLE ADF, 1972, BRIT J HAEMATOL, V22, P773
[10]  
KAMADA N, 1976, CANCER, V37, P2380, DOI 10.1002/1097-0142(197605)37:5<2380::AID-CNCR2820370530>3.0.CO