CHEMICO-ENZYMATIC SYNTHESES OF RACEMIC AND CHIRAL ISOMERS OF 7-METHYL-1,6-DIOXASPIRO[4.5]DECANE

被引：18

作者：

RAMASWAMY, S

OEHLSCHLAGER, AC

机构：

[1] Department of Chemistry Simon Fraser University Burnaby

来源：

TETRAHEDRON | 1991年 / 47卷 / 07期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4020(01)86372-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Porcine pancreatic lipase (PPL) mediated resolution of 6-heptene-2-ol afforded the enantiomers in high optical purities. Alkylation products of the dianion of the 2-4'-hydroxypentyl-1,3-dithiane prepared from the enantiomers, followed by alkylative hydrolysis, afforded 97% optically pure E-7-methyl-1,6-dioxaspiro[4.5]decane.

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收藏

页码：1157 / 1162

页数：6

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