DETERMINATION OF SODIUM MONOFLUOROACETATE (COMPOUND 1080) IN BIOLOGICAL TISSUES USING OXYGEN COMBUSTION AND A FLUORIDE SELECTIVE MEMBRANE-ELECTRODE

Sodium monofluoroacetate (SMFA) was quantitated in plasma and liver homogenates after total fluoride analysis using an oxygen combustion method and fluoride selective electrode. The organic content of the samples were estimated by difference between total fluoride and inorganic fluoride. Recoveries (%±SD) of SMFA in aqueous samples, plasma and liver homogenates were 99.1 ± 2.3, 95.2 ± 3.3 and 95.3 ± 2.9, respectively. The within-run coefficient of variation in the 10.0-0.072 mg/ml (or mg/g) range for all samples was 4.7% or less. The method is suitable for quantitation of SMFA in biological materials and as a laboratory diagnostic aid in cases of acute SMFA intoxication. © 1979.