GLYCOPROTEIN EXPRESSION IN MOUSE CEREBELLUM - EFFECTS OF INHIBITORS OF VESICLE FUNCTION

被引：3

作者：

CARROLL, M ^{[1
]}

BIRD, MM ^{[1
]}

机构：

[1] QUEEN MARY & WESTFIELD COLL, DEPT ANAT, LONDON E1 4NS, ENGLAND

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1991年 / 23卷 / 11期

关键词：

D O I：

10.1016/0020-711X(91)90230-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Explants of cerebellum from foetal mouse were cultured in vitro for 10 days in the presence of one of 5 inhibitors of vesicle function (ammonia, brefeldin A, carbonyl cyanide m-chlorophenylhydrazone, diethylcarbamazine, and monensin). 2. The effects of the inhibitors were compared with respect to: (a) the activity of enzymes involved in glycoprotein biosynthesis and degradation; (b) the expression of N-linked glycoproteins; (c) the morphology and ultrastructure of the cerebellar explants.

引用

页码：1293 / 1299

页数：7

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