ASYMMETRIC TOTAL SYNTHESIS OF (+)-JASPLAKINOLIDE

被引：95

作者：

CHU, KS ^{[1
]}

NEGRETE, GR ^{[1
]}

KONOPELSKI, JP ^{[1
]}

机构：

[1] UNIV CALIF SANTA CRUZ,DEPT CHEM & BIOCHEM,SANTA CRUZ,CA 95064

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 17期

关键词：

D O I：

10.1021/jo00017a037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent synthesis of the marine cyclodepsipeptide (+)-jasplakinolide has been realized. The synthesis of the required (R)-beta-tyrosine unit is accomplished via the stereospecific palladium-catalyzed arylation of an enantiomerically pure dihydropyrimidinone. The overall yield of the synthesis, based on the longest linear sequence, is 6.6%.

引用

页码：5196 / 5202

页数：7

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