HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF BENZODIAZEPINES USING SORBENTS WITH THERMALLY IMMOBILIZED CARBOWAX-20M

被引：11

作者：

CHOMA, I

DAWIDOWICZ, AL

LODKOWSKI, R

机构：

[1] Department of Chemical Physics, Marie Curie-Skodowska University, 20-031 Lublin

来源：

JOURNAL OF CHROMATOGRAPHY | 1992年 / 600卷 / 01期

关键词：

D O I：

10.1016/0021-9673(92)85444-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The use of siliceous supports (controlled-porosity glass or silica gel) with thermally immobilized Carbowax 20M as sorbents for the separation of benzodiazepines by high-performance liquid chromatography (HPLC) was studied. The physico-chemical and chromatographic properties of these sorbents were compared with those of LiChrosorb DIOL and LiChrosorb RP-18. The results indicate that normal-phase HPLC chromatography of benzodiazepines using sorbents with thermally immobilized Carbowax 20M is a simple and effective method characterized by a simple binary mobile phase, very short column equilibration, high selectivity and a short time of analysis.

引用

页码：109 / 113

页数：5

共 30 条

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