SPACER-MODIFIED DISACCHARIDE AND PSEUDO-TRISACCHARIDE METHYL GLYCOSIDES THAT MIMIC MALTOTRIOSE, AS COMPETITIVE INHIBITORS FOR PANCREATIC ALPHA-AMYLASE - A DEMONSTRATION OF THE CLUSTERING EFFECT

被引：44

作者：

BLANCMUESSER, M

VIGNE, L

DRIGUEZ, H

LEHMANN, J

STECK, J

URBAHNS, K

机构：

[1] UNIV FREIBURG, INST ORGAN CHEM & BIOCHEM, ALBERTSTR 21, W-7800 FREIBURG, GERMANY

[2] CTR RECH MACROMOLEC, CNRS, F-38041 GRENOBLE, FRANCE

来源：

CARBOHYDRATE RESEARCH | 1992年 / 224卷

关键词：

D O I：

10.1016/0008-6215(92)84093-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis is reported of methyl 4,4'-dithio-alpha-maltotrioside (12) and the spacer-modified disaccharide glycosides methyl 4-S-(4-alpha-D-glucopyranosylthio-2-hydroxybutyl)-4-thio-alpha-D-glucopyranoside (20) and methyl 4-S-[(1,5/4,6)-and (4,6/1,5)-4-alpha-D-glucopyranosylthio-5,6-dihydroxy-2-cyclohexen-1-yl]-4-thio-alpha-D-glucopyranoside (29a/b), which are analogues of methyl alpha-maltotrioside. The K(i) values for alpha-amylase for these compounds were determined as were those of methyl alpha-maltotrioside and maltose.

引用

页码：59 / 71

页数：13

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