GASTRO-PROTECTIVE EFFECTS BY EXTRACTS OF PETASITES-HYBRIDUS - THE ROLE OF INHIBITION OF PEPTIDO-LEUKOTRIENE SYNTHESIS

被引：42

作者：

BRUNE, K ^{[1
]}

BICKEL, D ^{[1
]}

PESKAR, BA ^{[1
]}

机构：

[1] UNIV BOCHUM,DEPT PHARMACOL & TOXICOL,D-44801 BOCHUM,GERMANY

来源：

PLANTA MEDICA | 1993年 / 59卷 / 06期

关键词：

PETASITES HYBRIDUS; CYTOPROTECTION; ULCER; PEPTIDO-LEUKOTRIENES;

D O I：

10.1055/s-2006-959746

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Extracts from Petasites hybridus are in therapeutic use for more than 2000 years. They have been claimed to improve gastrointestinal pain, lung-diseases such as asthma and cough, as well as spasms of the urogenital-tract. We have investigated these claims in animal models of gastro-intestinal ulcers and confirmed that alcoholic extracts of Petasites hybridus block the ethanol-induced gastric damage and reduce small intestinal ulcerations induced in rats by indomethacin. Searching for a possible mode of action, we found that ethanolic extracts of Petasites hybridus inhibit the peptido-leukotriene biosynthesis in mouse peritoneal macrophages but leave prostaglandin biosynthesis unimpaired. We conclude that the active principle could be useful in the treatment of gastrointestinal human diseases and that Petasites hybridus may contribute to the inhibition of calcium-dependent processes such as leukotriene biosynthesis.

引用

页码：494 / 496

页数：3

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