SERUM CONCENTRATIONS OF SOLUBLE INTERLEUKIN-2 RECEPTOR IN PATIENTS WITH RHEUMATOID-ARTHRITIS - EFFECT OF 2ND LINE DRUGS

被引：15

作者：

CRILLY, A

MADHOK, R

WATSON, J

CAPELL, HA

机构：

[1] GARTNAVEL ROYAL HOSP,DEPT RHEUMATOL,1053 GREAT WESTERN RD,GLASGOW G12 0YN,SCOTLAND

[2] GLASGOW ROYAL INFIRM,GLASGOW G4 0SF,SCOTLAND

[3] UNIV STRATHCLYDE,DEPT BIOCHEM,GLASGOW G1 1XW,SCOTLAND

来源：

ANNALS OF THE RHEUMATIC DISEASES | 1993年 / 52卷 / 01期

关键词：

D O I：

10.1136/ard.52.1.58

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Serum soluble interleukin 2 receptor (sIL-2R) concentrations reflect lymphocyte activation in vivo. An investigation was carried out to determine if sIL-2R concentrations correlate with existing disease activity parameters in patients with rheumatoid arthritis (RA) and whether these concentrations are modulated by treatment with second line drugs. Seventy nine patients with rheumatoid arthritis with active disease were prospectively treated with sodium aurothiomalate, auranofin, or sulphasalazine. Sequential concentrations of sIL-2R were measured by enzyme linked immunosorbent assay (ELISA). No correlations were observed between sIL-2R concentrations and clinical parameters and there were only moderate associations with concentrations of C reactive protein and the erythrocyte sedimentation rate. Concentrations of sIL-2R did not significantly change with treatment. It is concluded that sIL-2R probably measures an aspect of rheumatoid synovitis distinct from acute phase reactants and is not influenced by treatment with second line drugs.

引用

页码：58 / 60

页数：3

共 14 条

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