DACTYLOCYCLINES, NOVEL TETRACYCLINE DERIVATIVES PRODUCED BY A DACTYLOSPORANGIUM SP .3. ABSOLUTE STEREOCHEMISTRY OF THE DACTYLOCYCLINES

被引：10

作者：

DEVASTHALE, PV

MITSCHER, LA

TELIKEPALLI, H

VANDERVELDE, D

ZOU, JY

AX, HA

TYMIAK, AA

机构：

[1] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,WALLINGFORD,CT 06492

[2] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,PRINCETON,NJ 08543

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 12期

关键词：

D O I：

10.7164/antibiotics.45.1907

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The dactylocycline antibiotics were found through circular dichroism measurements, NMR spectroscopy and chemical transformations to possess the usual tetracycline family absolute configuration at carbons 4, 4a, 5a and 12a. The absolute stereochemistry about the C-6 carbon, however, was the reverse of that found with previously investigated tetracyclines.

引用

页码：1907 / 1913

页数：7

共 14 条

[1]

DOBRYNIN VN, 1962, TETRAHEDRON LETT, P901

[2] EXCITON CHIRALITY METHOD AND ITS APPLICATION TO CONFIGURATIONAL AND CONFORMATIONAL STUDIES OF NATURAL-PRODUCTS [J].