BLOCKADE OF DYNORPHIN-A(1-13) OVERT PSYCHOMOTOR EFFECTS BY NALOXONE

被引：7

作者：

ACETO, MD

BOWMAN, ER

机构：

[1] Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond

来源：

PEPTIDES | 1992年 / 13卷 / 04期

关键词：

DYNORPHIN-A(1-13); NALOXONE BLOCKADE; OVERT EFFECTS; RHESUS MONKEYS; OPIOID MECHANISMS;

D O I：

10.1016/0196-9781(92)90196-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Each of the dynorphin A(1-13) or dynorphin (dyn) treatment groups receiving naloxone showed a significant overall reduction of overt signs compared with the dyn controls. The data suggested that the overt psychomotor effects of dyn in the rhesus monkey were especially prone to blockade by naloxone, and probably involved opioid mechanisms.

引用

页码：847 / 849

页数：3

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